Environ Res. 2011
Nov;111(8):1249-57. doi:
10.1016/j.envres.2011.08.011. Epub 2011 Sep 9.
Scinicariello F1, Abadin HG, Murray HE.
Blood lead
levels (BLL) were significantly correlated with higher systolic BP among black
men and women, but not white or Mexican-American participants. BLLs were significantly
associated with higher diastolic BPs among white men and women and black men,
whereas, a negative association was observed in Mexican-American men that had,
also, a wider pulse pressure. Black men in the 90th percentile of blood lead distribution (BLL≥3.50 μg/dL) compared to black men in the 10th percentile of blood lead distribution (BLL≤0.7 μg/dL) had a significant increase of risk of having
hypertension (adjusted POR=2.69; 95%
CI: 1.08-6.72). In addition, blood cadmium was
significantly associated with hypertension and systolic and diastolic blood.
Neurotoxicology. 2018 Aug 8. pii:
S0161-813X(18)30167-0. doi: 10.1016/j.neuro.2018.08.001.
[Epub ahead of print]
Intermittent low-level lead exposure
provokes anxiety, hypertension, autonomic dysfunction and neuroinflammation.
Shvachiy L1, Geraldes V2, Amaro-Leal Â1, Rocha I3.
This study is the first to show that
developmental Pb exposure since fetal period can
cause lasting impairments in physiological parameters. The
intermittent lead exposure causes adverse health effects, i.e, hypertension, increased respiratory frequency and
chemoreflex sensitivity, baroreflex impairment, anxiety, decreased synaptic activity,
neuroinflammation and reactive gliosis, in some ways similar to a permanent
exposure, however some are lower-grade, due to the shorter duration of
exposure.
Indian J Clin Biochem. 2013 Jan;28(1):65-70. doi: 10.1007/s12291-012-0241-8. Epub
2012 Jul 27.
Dongre NN1, Suryakar AN2, Patil AJ3, Hundekari IA1, Devarnavadagi BB1.
The blood lead
levels and urinary lead levels of all workers were significantly increased
(P < 0.001) in proportion to the duration of lead exposure as
compared to controls. Systolic and diastolic blood pressure were significantly raised
(P < 0.001) in all three study groups of battery manufacture
workers as compared to controls. The
results of this study clearly indicate that the absorption of lead is more in
these workers which adversely affects blood pressure, disturbs calcium and phosphorus metabolism which
further impairs mineralization of bone resulting in decreased bone mineral
density observed in these workers. Lead toxicity is still persistent in battery
manufacture workers though they are using sophisticated techniques in these
industries. There is a need to protect the workers from the health hazards of
occupational lead exposure.
Environ Health Perspect. 2010 Feb;118(2):259-64. doi: 10.1289/ehp.0900866.
Scinicariello F1, Yesupriya A, Chang MH, Fowler BA; Centers for Disease Control and Prevention/National
Cancer Institute National Health and Nutrition Examination Survey III Genomics
Working Group.
BLL was
associated with systolic BP in non-Hispanic whites and with hypertension and
systolic and diastolic BP in non-Hispanic blacks. BLL was
not associated with BP outcomes in Mexican Americans. Non-Hispanic white ALAD2
carriers in the highest BLL quartile (3.852.9 microg/dL)
had a significantly higher adjusted prevalence odds ratio for hypertension
compared with ALAD1 homozygous individuals. We also found a significant
interaction between lead concentration and the ALAD2 allele in non-Hispanic
whites and non-Hispanic blacks in
relation to systolic BP.
BLL may be an important risk factor for hypertension and increased
systolic and diastolic BP. These associations may be modified by ALAD genotype.
Toxicol Ind Health. 2008 Oct;24(9):611-8. doi: 10.1177/0748233708098127.
Khan DA1, Qayyum S, Saleem S, Khan FA.
Lead is
a persistent toxic metal and associated with impairment of various
body functions in occupational workers. Results revealed that lead-exposed
workers had significantly high BLLs, median (range), 29.1 (9.0-61.1) microg/dL compared with controls, 8.3 (1.0-21.7) microg/dL. Oxidative stress (MDA, GGT) and inflammatory markers
(high-sensitivity CRP) were significantly increased (P < or = 0.05). Blood
pressure was raised, whereas hemoglobin was
decreased in exposed group (P < or
= 0.002). Serum urea, uric acid, phosphate, and ALT were significantly raised
in lead-exposed workers (P < or = 0.001). Serum albumin, total proteins, and
glomerular filtration rate (GFR) were decreased. Blood lead showed a significant positive correlation
with serum GGT (r = 0.63), MDA (r = 0.71), CRP (r = 0.75), urea (r = 0.34),
creatinine (r = 0.51), and uric acid (r = 0.29) (P < or = 0.01). It is concluded
that lead exposure increases oxidative stress that correlates with adverse
changes in hematological, renal, and hepatic function in the occupational
workers. Elevated blood lead
has positive correlation with oxidative stress, inflammatory and biochemical
markers that might be used to detect impairment in the body function in lead
exposed workers.
Diabetes Res Clin Pract. 2008 May;80(2):280-8. doi: 10.1016/j.diabres.2007.12.021. Epub
2008 Feb 13.
Afridi HI1, Kazi TG, Kazi N, Jamali MK, Arain MB, Jalbani N, Baig JA, Sarfraz RA.
The
results of this study showed that the mean values of Pb,
Cd and, As were significantly higher in scalp hair samples of smoker and non-smoker
diabetic patients as compared to control subjects (p<0.001). The
concentration of understudy toxic metals was also high in blood and urine
samples of DM patient but difference was more significant in smoker DM patients.
These results are consistent with those obtained in other studies, confirming
that toxic metals may play a role in the development of diabetes mellitus.
Biomed Res Int. 2013;2013:474963.
doi: 10.1155/2013/474963. Epub
2013 Jan 17.
Sirivarasai J1, Wananukul W, Kaojarern S, Chanprasertyothin S, Thongmung N, Ratanachaiwong W, Sura T, Sritara P.
in men
with blood lead >6.47 μ g/dL
the adjusted odds ratio (OR) of CRP levels for individuals with GSTP1 variants
allele, GSTM1 null, GSTT1 null, double-null GSTM1, and GSTT1 compared with
wild-type allele was 1.46 (95% CI; 1.05-2.20), 1.32 (95% CI; 1.03-1.69), 1.65
(95% CI; 1.17-2.35), and 1.98 (95% CI; 1.47-2.55), respectively. Our findings
suggested that lead exposure is associated with adverse changes in inflammatory
marker and SBP. GST polymorphisms are among the genetic determinants related
to lead-induced inflammatory response.
Environ Res. 2016
Aug;149:157-163. doi: 10.1016/j.envres.2016.05.015. Epub 2016 May 18.
Gambelunghe A1, Sallsten G2, Borné Y3, Forsgard N4, Hedblad B5, Nilsson P6, Fagerberg B7, Engström G8, Barregard L9.
Blood lead in the fourth quartile was associated with
significantly higher systolic and diastolic blood pressure (point estimates: 1-2mmHg) and increased
prevalence of hypertension (odds ratio: 1.3, 95% confidence interval: 1.1-1.5)
versus the other quartiles after adjustment for sex, age, smoking, alcohol,
waist circumference, and education. Associations were also significant with blood lead as a continuous variable.
Conclusion: Low-level lead exposure increases blood pressure and
may increase the risk of hypertension.
Toxicology. 2016 Jan
2;339:1-8. doi: 10.1016/j.tox.2015.11.004. Epub 2015 Nov 26.
Wildemann TM1, Siciliano SD2, Weber LP3.
exposure to lead by itself increased
oxidative stress and kidney damage along with blood
pressure,
the
prominent mechanism of action associated with the development of hypertension
seems to be oxidative stress and kidney damage for lead, while increased RAS
activation links methylmercury to hypertension
J Appl Toxicol. 2015
Aug;35(8):918-26. doi: 10.1002/jat.3092. Epub 2014 Dec 18.
Combined exposure to
lead, inorganic mercury and methylmercury shows deviation from
additivity for cardiovascular toxicity in rats.
Wildemann TM1,2, Weber LP1,3, Siciliano SD1,2.
combined
exposures negatively affected the electrical activity of the heart (synergism).
Thus,
it appears that estimates of blood total Hg levels need to
be paired with estimates of what species of mercury dominate exposure as well as whether lead
co-exposure is present to link total blood Hg levels to cardiovascular effects. Based on current human
exposure data and our results, there may be an increased risk of cardiac
events as a result of combined exposures to Hg(II), MeHg(I)
and Pb(II).
Blood Press. 2014 Dec;23(6):363-9. doi: 10.3109/08037051.2014.925228. Epub
2014 Jun 19.
Shiue I1.
Urinary mercury concentrations
were not significantly associated with high BP (OR = 1.19, 95% CI 0.97-1.48, p
= 0.095). ??Urinary cobalt (OR = 1.35, 95% CI 1.01-1.81, p = 0.044), lead
(OR = 1.77, 95% CI 1.31-2.38, p = 0.001), antimony (OR = 1.37, 95%
CI 1.09-1.72, p = 0.010) and tungsten (OR = 1.52, 95% CI 1.27-1.81, p
< 0.001) concentrations were observed to increase the risk of high BP.
There are no clear associations between environmental parabens and high BP. The
effect of environmental bisphenol A (OR = 1.14, 95% CI 1.00-1.30, p = 0.051)
disappeared after additionally adjusting for subsample weighting (OR = 1.12,
95% CI 0.93-1.35, p = 0.225). People with higher urinary
mono-2-ethyl-5-carboxypentyl phthalate (OR = 1.26, 95% CI 1.00-1.58, p =
0.051), mono-n-butyl phthalate (OR = 1.19, 95% CI 1.01-1.41, p = 0.042) and
mono-n-methyl phthalate metabolites (OR = 1.16, 95% CI 1.03-1.32, p = 0.021)
tended to have high BP. Moreover, urinary o-phenyl phenol concentrations (OR =
1.49, 95% CI 1.25-1.77, p < 0.001) and dimethylarsonic
acid concentrations (OR = 1.35, 95% CI 1.06-1.73, p = 0.019) were also seen to
be associated with high BP.
Urinary environmental chemical concentrations were associated with
risk of high BP, although the causal effect cannot be established. Elimination of
environmental chemicals in humans would need to be continued.
Environ Health Perspect. 2018 Jul 31;126(7):076002. doi: 10.1289/EHP2863. eCollection
2018 Jul.
A significant positive association between mercury and
hypertension and between mercury and
BP was identified. The exposure dose is an important factor in determining the
toxic effects of mercury on hypertension.
Environ Res. 2018
Apr;162:287-296. doi: 10.1016/j.envres.2018.01.026. Epub 2018 Feb 4.
Rizzetti DA1, da Silva TM1, Escobar AG1, Piagette J1, Peçanha FM1, Vassallo DV2, Alonso MJ3, Salaices M4, Wiggers GA5.
these
results suggest that AT-1 receptors upregulation might play a key role in the
vascular damage induced by Hg exposure by increasing oxidative stress and
probably by reducing NO bioavailability.
Ann Epidemiol. 2016 Aug;26(8):546-550.e1. doi:
10.1016/j.annepidem.2016.07.002. Epub 2016 Jul 14.
Associations
of blood heavy metal levels with intraocular pressure.
IOP and three BHMLs were significantly
associated with systolic and diastolic BP. But IOP was associated with
only blood lead and mercury levels.
J Hum Hypertens. 2015 May;29(5):309-15. doi: 10.1038/jhh.2014.87. Epub
2014 Oct 2.
Afridi HI1, Talpur FN1, Kazi TG2, Brabazon D3.
The
results of this study showed that the mean values of Cd and Hg were
significantly higher in scalp hair and blood samples
of hypertensive patients as compared with healthy controls, whereas Zn and Se
concentrations were found to be lower in hypertensive patients, the difference was significant
in the case of smoker patients (P < 0.001). The levels of both Hg &
Cd were 2-3-folds higher in scalp hair and blood samples
of nonhypertensive smoker subjects as compared with
nonsmoker controls. It was observed that exposure of TEs via cigarette smoking
may be synergistic with other risk factors associated with HT.
Environ Res. 2011
Aug;111(6):797-803. doi:
10.1016/j.envres.2011.05.005. Epub 2011 May 23.
Blood Mn level was associated with an increased risk
of hypertension in a representative sample of the Korean adult population.
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Patol Fiziol Eksp Ter. 2015 Jan-Mar;59(1):60-4.
[Role of activation of
lipid peroxidation in the mechanisms of cardiovascular disease system under the
action of heavy metals in the experiment].
prolonged intake of heavy metals (cobalt,
cadmium and mercury) leads to the development of marked hemodynamic
disturbances, combined with a sharp increase in the level of lipid peroxidation
products in the blood. Melatonin under intoxication by heavy metals
significantly reduced hypertensive effect of heavy metals on systemic hemodynamics,
which together with a
reduction of lipid peroxidation processes allows us to consider the activation
of lipid peroxidation one of the major pathogenic factor in the development of
hemodynamic disorders in conditions of heavy metal poisoning.
J Nanopart Res. 2017;19(9):320. doi:
10.1007/s11051-017-4004-6. Epub 2017 Sep 13.
Kurjane N1, Zvagule T1, Reste J1, Martinsone Z1, Pavlovska I2, Martinsone I1, Vanadzins I1.
Nanoparticles
affect immune functions, causing different immune responses. Our data showed a
statistically significant increased level of the pro-inflammatory cytokine
TNF-α in serum in both exposed groups compared with office workers as well as a
higher level of TNF-α in workers from the woodworking company compared with the
metalworking employees. We found an elevated level of IL-6 in the exposed
groups as well as an elevated level of IL-8 in the nasal lavage in woodworking
employees after work.