Persistent Organic Pollutants
Effects on Infant Thyroid
POPs from in-utero exposure were found to disrupt thyroid
function in newborns. The POPs were found to be at levels which generally
occur in the population. Adequate thyroid hormone level
in-utero is crucial for normal neurological development. Inadequate thyroid
during pregnancy can result in problems such as lower IQ, heart problems, and
short stature. All of these POPs are more toxic when iodine is deficient. Documentation follows: Prenatal
exposure to persistent organic pollutants and methylation of LINE-1 and
imprinted genes in placenta: A CHECK cohort study
2018 Oct;119:398-406.---
Association between
organohalogenated pollutants in cord blood and thyroid function in newborns
and mothers from Belgian population, Environ Pollut. 2018 Jul;238:389-396.
The last decades have seen the increasing prevalence of thyroid disorders. Logistic regression showed increased odds ratio for presentation of hypothyroid in mother for each one unit augmentation of log natural concentration of PFOA (OR = 2.30, [1.18-4.5]) and PFOS (OR = 2.03 [1.08-3.83]). Our findings showed that the residual contamination by PFCs and organochlorine pollutants in cord blood are correlated with thyroid hormone in the newborns and the risk of hypothyroid in mothers. Environ Res. 2014 Feb;129:47-51 Our data
demonstrated that DDT, β-HCH and HCB residues bioconcentrate in maternal and
cord sera. Moreover, the correlation analysis suggested that organochlorine
pesticides in maternal blood can transfer through the placenta and affect
newborn thyroid hormone levels. Environ Int. 2013 Sep;59:442-8. doi: 10.1016/j.envint.2013.07.009. Epub 2013 Aug 6. Several PCBs such as PCB28, 52, and 118 showed negative associations with T3 or T4. BDE47 and total PBDEs showed significant associations with T3 or T4. For OCPs, dichlorodiphenyltrichloroethanes (DDTs) and hexachlorobenzene (HCB) were generally associated with reduction of T3 or T4. Exposure to several target POPs were clearly related with potential for disrupting thyroid hormone balance among pregnant women, at the current level of exposure. Environ Health. 2020
Nov 26;19(1):127. doi: 10.1186/s12940-020-00679-7. Our results suggest that prenatal exposure to multiple PFASs was associated with thyroid hormones in cord blood. However, individual PFAS had varied effects-differing in magnitude and direction-on fetal thyroid hormones.
2018 Oct;119:398-406. doi:
10.1016/j.envint.2018.06.039. Epub 2018 Jul 10. Prenatal exposure to persistent organic pollutants and methylation of LINE-1 and imprinted genes in placenta: A CHECK cohort study, ,(significant
associations were detected between OCP measurements and placental DNA
methylation. Elevated concentrations of β-hexachlorhexane (β-HCH) in maternal
serum collected during delivery were significantly associated with a decrease
in methylation of LINE-1 in the placenta. Higher levels of
p,p'-dichlorodiphenyltrichloroethane (p,p'-DDT) in maternal serum were
associated with hypermethylation of insulin-like growth factor 2 (IGF2). In
multiple-POP models, a significant and positive association between DDTs and
IGF2 methylation was also observed. Placental LINE-1 methylation was
inversely associated with birth length. Our observations indicate that
prenatal exposure to several POPs including DDTs is associated with the
changes in methylation of genes, including major imprinted genes in the
placenta. )
Gestational exposure to endocrine disrupting chemicals in relation to infant birth weight: a Bayesian analysis of the HOME Study, 2017 Oct 27;16(1):115 (Gestational OPP, Pb, and PFAS exposures were most strongly associated with lower birth weight) Environmental Sci and Technology, 2016 Nov 15;50(22):12464-12472. doi: 10.1021/acs.est.6b03492.Epub 2016 Oct 26. Environmental Chemicals in an Urban
Population of Pregnant Women and Their Newborns from San Francisco
, et al Abstract
Exposures to
environmental pollutants in utero may increase the risk of adverse health
effects. We measured the concentrations of 59 potentially harmful chemicals
in 77 maternal and 65 paired umbilical cord blood samples collected in San
Francisco during 2010-2011, including polychlorinated biphenyls (PCBs),
organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs),
hydroxylated PBDEs (OH-PBDEs), and perfluorinated compounds (PFCs) in serum
and metals in whole blood. Consistent with previous studies, we found
evidence that concentrations of mercury (Hg) and lower-brominated PBDEs were
often higher in umbilical cord blood or serum than in maternal samples
(median cord:maternal ratio > 1), while for most PFCs and lead (Pb),
concentrations in cord blood or serum were generally equal to or lower than
their maternal pair (median cord:maternal ratio ≤ 1). In contrast to the
conclusions of a recent review, we found evidence that several PCBs and OCPs
were also often higher in cord than maternal serum (median cord:maternal
ratio > 1) when concentrations are assessed on a lipid-adjusted basis. Our
findings suggest that for many chemicals, fetuses may experience higher
exposures than their mothers and highlight the need to characterize potential
health risks and inform policies aimed at reducing sources of exposure. Researchers
studied the association between thyroid dysfunction in newborn babies and
their exposure to persistent organic pollutants (POPs) for a study published
in the journal PLOS One. Blood
umbilical cord and maternal blood levels of polychlorinated biphenyls (PCBs),
polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides (OCPs)
were compared with thyroid hormone in the umbilical cord blood and a blood
sample collected two days after birth. Special: Millions Suffer From Chronic
Conditions — Don't Know It's Their Thyroid POPs from
in-utero exposure were found to disrupt thyroid function in newborns. The
POPs were found to be at levels which generally occur in the population. Adequate thyroid hormone
level in-utero is crucial for normal neurological development. Inadequate
thyroid during pregnancy can result in problems such as lower IQ, heart
problems, and short stature. All of
these POPs are more toxic when iodine is deficient. Unfortunately,
iodine deficiency is occurring in the vast majority of Americans. One way to
diminish the toxicity of POPs and other endocrine disrupting chemicals is to
ensure adequate iodine intake. Dr.
David Brownstein, M.D., editor of the Natural Way to Health newsletter, is a
board-certified family physician and one of the nation’s foremost
practitioners of holistic medicine. In addition to his practice, Dr.
Brownstein has lectured internationally to physicians and is the author of
six very popular books. More
Links: 5 Simple Steps to Remove
Dangerous Toxins and Heavy Metals From Your Body's Cells |
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Millions Suffer From Chronic Conditions — Don't Know It’s
Their Thyroid Breakthrough remedy is radically Urgent Message From Dr. David
Brownstein, MD One of your body’s tiniest
glands — it’s located in your neck just above the Adam’s apple — is your
thyroid. It may be small and not look
important but it’s one of the most powerful glands in the whole body,
secreting hormones that are involved in just about every crucial function
that takes place in your body — heart, digestion, brain function, and more! So, it should not surprise
you to learn that if this tiny thyroid of yours is just a little off and not
working at 100 percent — your whole world could turn upside down! Sadly,
I have discovered in my medical practice so many of patients struggle with
conditions that are rooted in their thyroid — and they don’t even know it! In fact, many conventional
doctors just prescribe tons of prescription drugs that mask and
suppress symptoms but never fix the underlying problem of the
thyroid. Shockingly, many
doctors don’t even bother to test to see if the thyroid is
functioning at optimal levels. If you have experienced
unusual fatigue, rapid weight gain or loss that you can’t seem to fix,
frequent mood swings, sudden hair loss, unusual heart problems, sleepless
nights, frequent bathroom visits, even bouts of agitation and you find your
hands trembling — all of these problems may be linked to your thyroid. Many of my patients dismiss
these symptoms as nothing more than “age-related” problems. “Completely
normal for my age,” they will say. And, to top it all off, many of
my medical colleagues and even your doctor may have overlooked some vital
aspects of your blood results, ranking your thyroid as “normal” when it
really isn’t. But they are often wrong! And the longer these signs
are ignored, the more intense your health problems will become and worse you
will feel. Fortunately,
I developed a solution! As a medical doctor, I have
observed this happen with my patients for so many years I knew I needed to
provide help. Patients come in with signs
of thyroid imbalance and they have been to doctor after doctor looking for
real relief.
And here is the surprising
truth: Many times patients can be cured just by getting simple
nutrients they are missing into their body — nutrients that cause no
side effects and can radically change the way they feel. After seeing so many cases
like this, I decided to take matters into my own hands. So I created a formula
containing these simple nutrients that my patients could take to fix their
thyroid problems and feel better once and for all. My formula is not something I
slapped together in a big rush. It came after years of
intense research, and treating thousands of patients. Only then did I join with
Medix Select, one of the nation&rsuo;s premier nutraceutical companies,
to make an effective product for my patients and people like you. This amazing product is called Actalin®. Well, since my formula Actalin was
launched in 2013, Medix has sold more than 350,000 bottles — it’s most
popular nutritional supplement. My patients and others have
never been happier because they saw their lives turn around! I love hearing their success
stories so I asked Medix Select if I could share their testimonials. Here are just a
handful of the overwhelming positive responses we have received
after consumers tried Actalin for themselves: This has changed my life! I have been taking Actalin for two
months. I have a new life. I cannot thank Dr. Brownstein enough. Truly this
is the answer to my suffering thus far. I'm telling everyone I know about it. I knew I had a problem with my thyroid when I experienced rapid
weight gain, fatigue and just not feeling right. I searched online to see if
it could be my thyroid and all the things you mentioned in your testimonial
were relevant to me! I ordered a bottle [and] within a very short period of
time got back to the way I was when I felt great every morning. My energy
returned and my brain was reactivated. I don’t feel the need to sleep during
the day and I feel years younger. I love Actalin! It improved my health and
my energy level. This definitely was a godsend! I ordered Actalin for my wife because her prescription for
thyroid was not doing anything for her condition. After three days of use,
she is like a new person. Thanks very much. I am a 48-year-old woman who has struggled with issues for more
than 20 years. I got on the Big Pharma cycle of drugs and felt even worse. I
stopped the meds and have been trying to use natural ways and I have been
following Dr. Brownstein for almost a year, and it was his information about
iodine deficiency and all the symptoms it causes that led me to try the
Actalin. My life has changed. I have more energy now than I did when I was in
my 30s. I am actually looking forward to going in for my yearly physical with
my doctor! I bought this for my wife. She tried it for a few weeks now and she
feels much better. Awesome job, Dr. Brownstein! My wife is very happy about
it.
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